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The FAK-paxillin pathway is central to cell adhesion, migration, and proliferation

The strategy included the crossing of mice with floxed allele of Jnk1 , generated by homologous recombination in ES cells and backcrossed to the C57BL/6J strain with Jnk2 -deficient mice to generate Jnk1 LoxP/LoxP / Jnk2 -/- mice

Conversely, CO-GHD patients tend to be less insulin-resistant than AO-GHD patients (84), and their IGF-I levels are generally lower than their AO-GHD counterparts due to relatively lower intra-portal insulin levels